The shooting happened at about 6 a.m. in the 600 block of S. San Pedro Street, near 6th Street, according to the LAPD.
The man was shot and transported to a nearby hospital, where he later died. His identity was not released.
Authorities said a suspect used a handgun in the shooting and then ran from the scene.
Investigators said they did not yet have a good description of the suspect.
DEVELOPING: We will add more details to this report as they become available.