"Ratatouille" went into the ceremony at UCLA's Royce Hall with a leading 13 nominations.
Among it awards were best writing and directing for Brad Bird, best voice acting for Ian Holm, best character animation, music, storyboarding, production design and best animated video game.
Bird and two writing partners are also up for an Oscar for best original screenplay.
"Ratatouille" is the tale of a rat voiced by Patton Oswalt that tries to rise above the trash-nibbling ways of his family and friends.
The Annie Awards are presented by The International Animated Film Society. The best-picture winner has gone on to win the Academy Award for animated feature every year but one since the Oscars added the category in 2001. Last year's Annie winner, the Disney-Pixar auto-racing comedy "Cars," lost at the Oscars to the penguin musical "Happy Feet."
Other Annie Awards presented Friday included:
- Animated Effects: Deborah Carlson, "Surf's Up."
- Animated television production: "Creature Comforts America," Aardman Animation.
- Animated television production for children: "El Tigre," Nickelodeon.
- Directing in an animated TV production: Seth Green, "Robot Chicken Star Wars," ShadowMachine.
Disney is the parent company of ABC7.
