Often running under a hail of confetti, more than 50,000 strong, some survivors, some paying tribute to those who lost the fight, but all united in the same cause -- defeating breast and ovarian cancer.
"It means celebrating me and getting the information out there for women to take care of themselves," said cancer survivor Klanga Pallcia.
There were lots of tears and hugs during the event as participants honored their loved ones affected by cancer and survivors celebrated their brave battle.
"Sometimes you think you're alone there, and there's just so much people caring and through this whole thing I've met so many people that are so caring and loving," said cancer survivor Rosalia Velasquez.
The race has been a longstanding annual tradition on the Saturday before Mother's Day, and participants say there's no better way to honor the women in their lives.
ABC7 was a proud sponsor of the race. Eyewitness News personalities Michelle Tuzee and Ellen Leyva helped with opening ceremonies, and the morning news team cheered participants along the route.
The host this year was be Tom Selleck, as well as 'Dancing with the Stars' host Carrie Ann Inaba.
"It is so much fun being with the other survivors and just seeing how we made it through all the medical problems we had to go through. So, it's really good. I really enjoy coming," said cancer survivor Elizabeth Washington.
Since the event's inception in 1993, over $50 million has been raised in research money for women's cancers.