The journey was a little more than a city block, but it took three hours for workers to roll the structure to its new location in St. Nicholas Park in Harlem.
The founding father lived in the home in northern Manhattan for two years before his death in a duel in 1804. Congress made it a national memorial in 1962.
The National Park Service is moving the building so it can be restored.
Also known as the Hamilton grange, the house was moved once before, in 1889.