"Commuters all throughout Los Angeles who were promised traffic relief, today we can say we're here to deliver," Villaraigosa said during a press conference.
The project encompasses Howard Hughes Parkway to the north, La Cienega to the east, Imperial Highway to the south and Vista Del Mar on the west side.
Each stop light is marked with a blue signal to mark which lights are part of the project.
There are 136 new traffic lights, nine new left turn signals, two traffic information message signs and 10 traffic surveillance cameras so that engineers can manually adjust lights to keep traffic flowing.
"You'd be spending more time with your family, more time at work, more time doing more things for the city of Los Angeles," said L.A. City Councilwoman Wendy Greuel.
The project is expected to ease traffic by as much as 15 percent.
The city plans to have all of its traffic lights synched up by the year 2012, and Eagle Rock and North Hollywood are next up.