Police say that the woman is in her 20s and has a European accent.
The unsuspecting victim invited her to his room and she complied.
"She asked for a glass of wine and he complied with that. He left for the bathroom and when he came back the last thing he remembers is drinking some of the wine," said Lt. Tony Lee, Beverly Hills Police Department.
Authorities say she stole $35,000 worth of designer wear, including a $20,000 Rolex watch.
"He wakes up several hours later and finds out that he's missing his Rolex watch from his wrist, a lot of high-end designer products like Hermes watch, Ray Ban products, Louis Vuitton, Prada, you name it," said Lt. Lee.
The hotel surveillance video shows the woman leaving in a cab. She was dropped off in West Hollywood.
Police say that the man she robbed may not be the first victim.
"There is a very strong possibility, and that is why we think there are other victims out there. There is a very strong likelihood that, that is the case," said Lt. Lee.
Beverly Hills police say that they do not know much about the suspect. They are still trying to figure out what type of drug she used.
"Right now we are running some test trying to ascertain what kind of drug it was. He was out for approximately seven hours," said Lt. Lee.
If you recognize that woman or have any information on this case, you're urged to call Beverly Hills Police at (310) 550-4951.