Bryant was 14-of-23 from the field, part of Los Angeles shooting 54 percent on the night.
Pau Gasol had 15 points, seven rebounds and had six assists in his return to Memphis. Gasol played six-plus seasons with the Grizzlies before being traded to Los Angeles in February.
Gasol is the Grizzlies franchise leader in 12 statistical categories, including points, rebounds and blocks, and the only All-Star in Grizzlies history (2006).
He was met with a mixture of cheers and boos in the pregame introductions. Later, when the Grizzlies presented a video tribute during a timeout, the boos were louder.
Rudy Gay led Memphis with 23 points, while O.J. Mayo scored 22 and had six assists.
Andrew Bynum had 13 points and Lamar Odom finished with 12.
The game was close throughout without either team building a lead of more than eight through the first three quarters. The Lakers had lost their last two games on the road - at Miami and Orlando - by a total of five points.
Memphis led 57-49 at the half and couldn't pull away in the third quarter. The two teams got testy as Marc Gasol and Bryant drew technicals. Odom would also draw one for arguing a no-call later in the half.
The two teams exchanged leads late in the third period before Memphis carried an 80-77 lead into the fourth quarter.
Notes: Monday was the final game of a season-long five-game homestand for the Grizzlies. After winning the first two, Memphis lost three straight. ... Earlier in the day, the Lakers announced that a pair of doctors had confirmed Jordan Farmar suffered a torn lateral meniscus and will need surgery. He could be sidelined for eight weeks.
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