The men gagged the man, tied him to a chair and slapped him.
They fled with a substantial amount of jewels and cash from the safe.
The jewelry store owner was not seriously hurt.
The robbers were described as Latinos in their early 20s, about 5 feet 11 inches tall, with short hair in a buzz-cut. One wore a red jacket and the other a white jacket. No vehicle was seen.
Anyone with information is asked to call the Orange County Sheriff's Department at (714) 628-7170.
City News Service contributed to this story.
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