His closest challenger was Walter Moore, a local attorney, but Moore finished with only 26 percent of the vote.
During Villaraigosa's acceptance speech Tuesday night, he thanked his supporters and promised to work hard to get the city of Los Angeles through the tough economic time.
On Wednesday morning, the mayor met with parents at an elementary school in Boyle Heights. He told those at the meeting that he would continue to push for better schools.
The other big question now is whether the mayor will run for governor in 2010, which many are speculating. Villaraigosa on Wednesday did not rule out a run for governor.
"If you were confronted, be honest, with the possibility of serving as governor of the state of California, would you not consider it? Anybody would consider it. This is a big thing, what an honor," he said.
For L.A. city controller, Councilwoman Wendy Greuel won convincingly, with about 65 percent of the vote. Greuel had name recognition on her side, and a lot of money to spend campaigning. She put on a lot of commercials, and they clearly paid off.
Greuel will now be taking over for Laura Chick, who was termed out. Greuel was termed out for city council, so she will just shift over to the city controller's office. She is promising to keep a close eye on how the city spends taxpayers' money.
Her closest challenger was Kathleen Evans, who ended up with 19 percent of the vote.
Weiss ended with 36 percent of the vote, while Trutanich finished with 27 percent of the vote.
Trutanich is a former deputy D.A. and has also run a private practice. Weiss had the support of LAPD Chief Bill Bratton, which was controversial to some, but it didn't help him enough.
The only surprising result of the election was the extremely low voter turnout. Only 13.14 percent of eligible voters took part in Tuesday's election. The last time Villaraigosa ran for mayor, the voter turnout was 30 percent.
Eyewitness News Reporters John Gregory and John North contributed to this report.
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