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Authorities said the incident began with a relatively minor collision involving two cars around 6 a.m., just east of the Irwindale exit. The drivers pulled to the side of the freeway when they heard screeching tires.
CHP Officer Edmund Zorilla said a stake-bed truck rear-ended another truck that was carrying fences.
"Those fences came down on that vehicle, that vehicle lost control," Zorilla said.
The man driving the truck carrying the fences was thrown from the vehicle and died at the scene. The man was identified as a 30-year-old Hispanic male.
A woman driving a black car somehow got involved in the collision, and was killed after being pinned inside her vehicle. That victim was identified as a 70-year-old white female. Crews had to extricate her body from the rubble.
Just east of the collision, a Foothill Transit bus also got involved, but police are unsure how it pieces together, Zorilla said.
He said the bus hit a GMC pickup truck, and the victim in the truck was airlifted to the hospital in critical condition.
Three other people suffered minor injuries.
Authorities said there are a lot of unanswered questions.
"We're trying to gather witness statements right now to find out, was traffic slowing? Was something obstructing your view? We just don't know," Zorilla said.
Crews worked for hours to clear the wreckage, and investigators combed the scene for clues Friday.
All lanes of the 210 East and West were shut down initially while a patient was airlifted out. All eastbound and westbound lanes of the 210 are open.
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