The men in the truck allegedly jumped out and attacked the men, then jumped back into the truck and fled the scene.
Lt. Ted Boyne of the Orange County Sheriff's Department said the men in the truck are suspected of being members of a San Clemente gang.
The victims were taken to Mission Hospital in Mission Viejo in critical condition.
MORE LOCAL HEADLINES FROM ORANGE COUNTY
SEND TIP || REPORT TYPO || TWEET @abc7 || WIDGET