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Homeowner Dorothy Inouye was uninjured because she happened to be in the kitchen mopping the floor at the time of the accident.
"I'm lucky to be alive," Inouye said.
"It sounded so big, sounded like maybe a plane crashing, but not like an earthquake," she said.
Police said the big rig was traveling northbound a slope on Corporate Center Drive when the driver lost control.
"We were watching the football game, and it sounded like a combination of a train wreck and a hurricane," said neighbor Ralph Berg.
The truck smashed right into Inouye's bedroom, but luckily, she had opted to do some late-night cleaning in the kitchen.
"So I ran outside and I saw this big trailer in my yard, and then there was another trailer in front of that, and the cab was in my bedroom, but it had gone through my bedroom and the next bedroom," Inouye said.
The driver was nowhere to be found when authorities arrived.
The violent collision was no surprise to some residents, who said the downhill road that runs parallel to the freeway has been a safety concern for years.
Neighbor Rene Santos said vehicles driving on that road are traveling way over 45.
"Sometimes it's even 50, 55," he said.
In the meantime, the house has been red tagged, and Inouye said she'll be staying with family members until the mess is cleaned up.
Anyone with information is urged to call the Monterey Park Police Department at (626) 307-1238.