The two wounded are hospitalized with non-life threatening injuries.
It happened on the 200 block of West 20th Street, about 10:45 p.m.
Police say they're looking for at least two suspects.
A witness says the gunmen appeared to walk up to the victims and opened fire.
No word yet on a possible motive for the shooting.
The names of the victims have not been released.
City News Service contributed to this report.