The fat is particularly harmful since it surrounds the abdominal organs and is linked to type 2 diabetes, high blood pressure and heart disease.
Scientists found that women with bigger skirt sizes had a greater risk of endometrial cancer, while the men with bigger trouser sizes had a greater risk of kidney cancer.
The researchers conclude that clothing size reflects fat distribution that's not indicated solely by height and weight measurements.
They say their results show clothing size is a useful measure to predict cancer risk where waist measurements are not available.
They suggest it may be useful for researchers to collect data on clothing sizes in addition to weight and height measurements, especially in populations where measuring waist circumference is difficult because of cultural issues or extreme obesity.
Their results are based on information on nearly 2,500 men and women enrolled in a large study of diet and cancer.