Three police officers responded to a robbery-in-progress call on the 2000 block of South Susan Street just before 2 a.m. Monday
At the scene of the shooting, investigators collected evidence all morning. There were numerous bullet casings on the ground, evidence of multiple shots fired.
Police were not saying whether the suspects were armed.
"They're still trying to put the pieces together, said Santa Ana Police Corporal Anthony Bertagna.
Police said the two suspects jumped into a Chevrolet Blazer, then led police on a pursuit that lasted less than a mile.
"The helicopter was on scene. He followed the vehicle, as well as the officers, to Edinger and Fairview, where the suspects spun out of control and were taken into custody," said Bertagna.
Inside the bullet-ridden vehicle, police identified the driver as Anthony Martin Del Castillo, a 47-year-old parolee from Santa Ana, convicted of grand-theft and burglary in 2008, who was wanted on a no-bail warrant. He was killed.
Elpidio Gerald Antolin, 54, of Garden Grove, was hospitalized after being shot, Bertagna said. Antolin was expected to survive.
No officers were hurt in the incident.
There are several businesses within the same building, including an iron works business and a glass company. Police have not said which business was being targeted by the suspects.
The Orange County District Attorney's Office was assisting with the investigation, which is standard practice.