A suspect was taken in custody and an ambulance was requested at the scene.
The fight occurred near the intersection of Ventura Blvd. and N. Topanga Canyon Blvd.
Eastbound traffic on Ventura Blvd. was slow, but westbound traffic was at a standstill due to multiple police cars and fire engines on scene.
The suspect was subdued by at least six to eight officers, then strapped face-down to a gurney and loaded onto an ambulance. The suspect could be seen repeatedly banging his head on the gurney.
The suspect was confirmed as a bus passenger. MTA bus service was affected on the Ventura Blvd. route.
According to MTA spokesman Jose Ubaldo, MTA bus line 161 was traveling from Canoga Park to Thousand Oaks at 4:57 p.m. A male passenger inside the bus was reportedly harassing a female patron. The bus driver stopped the bus and called for deputy assistance.
The suspect gave the deputy a hard time when he arrived. The deputy called for more assistance. During a scuffle, someone used pepper-spray inside the bus, and the bus driver was hit, according to Ubaldo.
The suspect was treated by paramedics on scene and transported to a hospital.
The bus was cleared of passengers due to lingering pepper-spray inside.