The singer will be joined by economist Jeffrey Sachs, a development affairs expert and mentor of the initiative.
Madonna has been very active throughout the years with her charitable efforts in Malawi. She is expected on Tuesday to lay the first brick of her Raising Malawi Academy for Girls.
Construction of the school is estimated at $15 million and is set to open in 2011.
Madonna has adopted two children from Malawi.
The Associated Press contributed to this report.