The fundraiser is scheduled to take place in the afternoon at Exposition Park.
The post-fundraiser reception at 4:30 p.m. will take place at the California Science Museum, followed by a dinner at the Natural History Museum. Tickets cost $250-2,500 for the reception and $35,000 per couple for the dinner.
The president is coming via helicopter but police warn some streets may be closed north of the Memorial Coliseum, creating heavier traffic in the area.
CNS contributed to this report.