They were both taken to L.A. County USC Medical Center where they are currently in serious but stable condition.
Investigators believe the suspect was driving a red minivan and fled the scene heading toward Vermont Avenue.
"What we have right now is a possible sports utility vehicle that fled immediately after the accident. The pedestrians sustained severe injuries which makes this a felony hit-and-run," said LAPD Sgt. Emanuel Sanchez.
Anyone with information is asked to call 1-877-LAPD-24-7 or 1-877-527-3247.