The victims, three men and a 25-year-old woman, were taken to Harbor-UCLA Medical Center. Ronald Reeves, 42, died from his injuries, according to the Los Angeles County coroner's office.
The three other victims remained hospitalized in unknown condition.
Police said they don't have a motive for the shooting and no arrests were made. It is unknown if it was gang related.
Anyone with information was urged to call the LAPD Southeast Station at (213) 972-7828.