"I would like to say, once and for all, to all the people who say, 'How are you?': I'm FINE!" Walters told viewers.
Joining the welcome party was David Letterman in his first visit. The "Late Show" host had open-heart surgery a decade ago.
Letterman recalled when he got the post-surgery good news from the doctor.
"He puts his hand on my shoulder and he said, 'Everything went great.' And that was the best part of the whole thing - that and, later, the sponge bath," he cracked.
"The View" is starting its 14th season. Other hosts are Joy Behar, Whoopi Goldberg, Elisabeth Hasselbeck and Sherri Shepherd.
The Associated Press contributed to this story.
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