The body was discovered around 5:45 a.m. by a passerby approaching to catch a bus.
Detectives are investigating the death as a homicide, but they have yet to find out the identity of the victim. Authorities said the victim is believed to be in her 50s, but she had no purse and was not carrying any form of identification.
Santa Ana police said there is typically a lot of foot traffic in the area where the body was discovered, and they hope someone with information will come forward.
"Potentially, it could have been a robbery. It could have been some kind of altercation. Possibly, she fell out of her wheelchair and did it to herself," said Santa Ana Police Department Cpl. Anthony Bertagna.
"At this point, we have nothing. So we're hoping that someone who was in the area or driving by might be able to provide us with some information," Bertagna added.
Authorities believe the woman may have been homeless. An autopsy is scheduled for Thursday.
If you have any information about this case, you're urged to call the Santa Ana Police Department at (714) 245-8400.