"It's gonna be terrible all the way from 8 a.m. when traffic for work starts. It's just going to be terrible all day," said Neilou Mogharabi, a USC student.
"It affects our work, it affects our coming and going to work, it affects people coming to our box office at the sports arena," said Ron Lederkramer, who works at the nearby sports arena.
Lederkramer was one of the thousands of drivers trapped in the traffic nightmare on the Westside during the president's last visit in August when his motorcade shut down streets for hours.
The traffic tie-up has become so contentious it's even become part of the negative campaigning.
On Thursday the Carly Fiorina campaign created a web-only commercial on YouTube attacking Barbara Boxer, using local news reports, including one from Eyewitness News, about the traffic jam from the last presidential visit.
Traffic will be affected again but hopefully not to the same extent as the president will reportedly be going by helicopter from the airport to USC.
The main streets will be shut down around campus much of the day.
"These are busy streets, so when you close them off or shut them down the problem gets displaced to streets in the surrounding areas. It radiates outward," said Lt. John Romero of the Los Angeles Police Department.
In a statement, the secret service said, "The Secret Service works closely with their local counterparts including the LAPD and CHP to come up with a traffic pan that minimizes problems for residents."
Those who live and work in the area know that no matter what it's going to be a challenge.
Street closures near USC will be in effect from late morning into mid-afternoon.
Martin Luther King Boulevard will be closed between Figueroa Street and Vermont Avenue to through vehicle traffic from 9:30 a.m. until 11:25 a.m. and to all traffic from 11:25 a.m. until 2:50 p.m.
Vermont Avenue will be closed between Martin Luther King Boulevard and Exposition Boulevard to through vehicle traffic from 9:30 a.m. until 11:25 a.m. and all traffic from 11:25 a.m. until 2:50 p.m.
Figueroa Street will be closed between Martin Luther King Boulevard and 39th Street to through vehicle traffic from 9:30 a.m. until 11:25 a.m. and all traffic from 11:25 a.m. until 2:50 p.m.
City News Service contributed to this report.