Ebron and others smuggled hundreds of pounds of cocaine from Southern California to Baltimore, according to authorities.
Authorities seized nearly 300 kilograms of cocaine and $1.1 million.
Investigators used wiretaps to track the shipments that didn't slow down despite the discovery of nearly 50 kilograms of cocaine aboard a plane during a refueling stop in September.
"It's amazing what greed will do to you," said Assistant U.S. Attorney Rob Villeza. "They knew something was going on, but the next day they were doing it again. They were not prepared to stop."
If convicted, each of the defendants could face up to life in prison.
The Associated Press contributed to this report.