The writer-director of the movie said his production team is negotiating with another actress for the role of the 1970s porn star and will make an announcement soon.
According to some media reports, the troubled starlet quit the movie in order to focus her attention on her rehab for drug addiction. However, other reports say Wilder purposely dropped her for another actress.
In October, a judge ordered Lohan to rehab. It was her fifth time in court since May.
The 24-year-old is expected to be in a rehab facility until at least Jan.3.
The Associated Press contributed to this report.