L.A. Fire Department officials said an additional 62 people were also treated on site for a variety of minor injuries and illnesses.
Several people were also arrested on suspicion of drug possession.
Nearly 26,000 people attended the 13th annual Together As One electronic music festival, which began at 5 p.m. Friday and ended at 2 a.m. New Year's Day.
One possible ecstasy overdose patient was said to be a dialysis patient.
Raves had been banned at the arena in June after a 15-year-old girl overdosed and died at a rave there.
However, commissioners lifted the ban in November.
The Associated Press contributed to this report.