If the jackpot is won by a single California ticket, it will be the largest Lottery jackpot ever won in California.
Besides the jackpot, prizes range from $2 to $250,000. Drawings are held every Tuesday and Friday night.
The largest Mega Millions jackpot was $390 million in 2007. The prize was shared by two players in Georgia and New Jersey.
The game is available in 41 states and the District of Columbia. Tuesday's drawing was scheduled for 8 p.m.
The Associated Press contributed to this report.