The graffiti threatens multiple ethnic groups, as well as Catholics.
The latest message, filled with spelling errors, threatens violence against Mexican, Asian, African-Americans and Catholics.
The hateful words were left on a wall in between a furniture store and a pet clinic in Anaheim Hills. The vandalism happened between Monday night and Tuesday morning.
"Some person was leaving very hateful messages," said Anaheim Police Sgt. Rick Martinez. "We've had a total of three in our city that were reported on the morning of the 11th."
Someone scrawled a message on the side of St. Boniface Roman Catholic Church in Anaheim.
A mile and a half away, a 40-foot-long message, now cleaned up, was spray-painted outside a Chase Bank in Anaheim. Police say the message threatened death to Asians and African-Americans.
The racial epithets were similar to a message left at the entrance to the Orange County Housing Authority offices in Santa Ana.
A 10-minute drive away, someone spray-painted "Kill Catholicks" outside St. Thomas More Catholic Parish in Irvine on the walkway. That was discovered Tuesday morning.
"Unfortunately every community sees graffiti, but to have messages like this is very troubling," said Martinez.
Police are reviewing surveillance video from the church parking lot in Anaheim. A white minivan drives in around 3 a.m. Tuesday. The person gets out and heads toward the church. Minutes later, he or she walks back to the van and leaves the area.
"Right now we don't know specifically who may be responsible for this. We're trying to determine if the suspect is actually a male or female," said Martinez.
Crews acted quickly to remove the vandalism.
Police are trying to determine if the same person is responsible for all five hate crimes.
If you have information related to these cases, you're asked to call Anaheim Police at (714) 765-1900.