The woman was transported to an area hospital, where she was pronounced dead. The identity of the victim was not immediately released.
The driver was described as a Hispanic man with a beard and the suspect vehicle was described as a beige or gray Ford F-150. Authorities said the truck may have front end damage.
CHP said the driver may have headed eastbound on Gage Avenue from Figueroa to the 110 Freeway.
If you have any information regarding this incident, you're urged to contact the Los Angeles Police Department at (877) LAPD-24-7 or (877) 527-3247.
City News Service contributed to this report.