The DGA award is traditionally a strong indicator of who will win the directing Oscar.
Only six times in the 62-year history of the Guild Awards has the winner failed to take home the Oscar.
For the 23rd time, Carl Reiner hosted the ceremony in Hollywood.
To be back here a second time is extraordinary," said Hooper, an Emmy winner for the miniseries "Elizabeth I" and a previous Directors Guild nominee for the miniseries "John Adams."
The Associated Press contributed to this report.
