The interview is set to air Thursday, Feb. 24. Officials with Chicago-based Harpo Productions say the interview will cover Vick's time in prison, his work with the Humane Society and his return to the NFL.
Vick served 18 months in prison for his involvement in an illegal dogfighting operation. In 2007, several dogs were seized from his property in Surry County, Va.
He was reinstated to the NFL for the 2009 season and has been doing public-service work, including with the Humane Society.
This is the 25th and final season of "The Oprah Winfrey Show."
The Associated Press contributed to this report.