The pedestrian was walking along a crosswalk in the intersection of Harbor Boulevard and Katella Avenue at approximately 2 a.m. when she was struck by a car traveling north on Harbor Boulevard.
The car initially stopped but drove away after a short time, leaving the injured woman on the street.
The victim was transported to a local trauma center, where she was listed in critical condition with life-threatening injuries.
Witnesses described the suspect vehicle as a mid-1990s to mid-2000s white Honda Accord or Nissan Altima or Maxima. The driver was described as a Hispanic male in his mid 40s.
The identity of the victim was not immediately released but officials said she is of Asian descent.
Anyone with information regarding this incident is urged to contact Anaheim Police Traffic Investigators at (714) 765-1900.