The movie finished No. 1 at the box office this weekend with $38 million.
It features Johnny Depp as the voice of the chameleon sheriff, Rango.
This is the first animated film from Industrial Light & Magic, which is the special effects studio founded by George Lucas.
"The Adjustment Bureau," starring Matt Damon, finished second with just under $21 million.
In third, was "Beastly," taking in $10.1 million.
Rounding out the top five are the raunchy comedy "Hall Pass" and the animated film "Gnomeo and Juliet."
The top 10 movies were: The movie finished No. 1 at the box office this weekend with $38 million.
1. "Rango," $38 million.
2. "The Adjustment Bureau," $20.9 million.
3. "Beastly," $10.1 million
4. "Hall Pass," $9 million.
5. "Gnomeo and Juliet," $6.9 million.
6. "Unknown," $6.6 million.
7. "The King's Speech," $6.5 million.
8. "Just Go With It," $6.5 million.
9. "I Am Number Four," $5.7 million.
10. "Justin Bieber: Never Say Never," $4.3 million.
The Associated Press contributed to this report.
