Authorities responded to the 3100 block of North Fond Drive at 7:21 a.m. Smoke could be seen for miles from the blaze.
The 68-year-old former Mouseketeer was one of three people taken to a hospital with possible smoke inhalation. Funicello has reportedly been in declining health with multiple sclerosis.
The fire caused extensive damage to the one-story home. It took firefighters about 25 minutes to knock down the flames.
An estimate of the damage to the approximately 3,600-square-foot home was not immediately available.
Funicello was a Mouseketeer on Disney's "Mickey Mouse Club" in the 1950s.
City News Service contributed to this report.