Cox recently opened up about the separation in an interview with Harper's Bazaar for their April issue. She said she doesn't hold the fact that Arquette fooled around with another woman while they were separated against him.
"He absolutely did nothing that wasn't in the boundaries of what we set for our separation, so there's nothing to judge," Cox told Harper's Bazaar, as reported by x17 Online. "I may not have known about it, but that's the only difference."
Cox also said told Harper's that she really hoped that her marriage could be repaired because she still has strong feelings for Arquette.
"If [the marriage] doesn't work out, I will have huge waves of pain about failing in that department," Courteney told Harper's Bazaar. "But right now I don't have that because I don't know what the future holds and I guess because I have strong feelings for him."
Arquette appeared on "The Oprah Winfrey Show" in February and said that he would love to "work out" his marriage to Cox but wants her to be happy, even if it is not with him.
"I want her to be happy," the actor told Oprah Winfrey, as reported by People magazine. "If me being the best person I can be doesn't make her happy in a partner, in who she needs, whatever she's looking for, that's still to be answered."
The couple met on the set of the 1996 horror film "Scream." Arquette, 39, and Cox, 46, married in June 1999 and have a 6-year-old daughter named Coco. They announced in October 2010 they had agreed to a trial separation.
Arquette spoke about his love life on Howard Stern's Sirius XM satellite radio show soon after he and Cox announced their trial separation, and said the two had not been intimate in months. He later apologized for revealing too much.
Cox and Arquette star together in "Scream 4", which is due for release on April 15, 2011. A trailer was released earlier in the week, watch it below.