The sci-fi thriller, starring Bradley Cooper, opened at No. 1 with $19 million.
Cooper plays a struggling writer who takes a magical pill that allows him to tap into his maximum brain potential. Suddenly he's successful and making millions.
Coming in second is the animated western "Rango" with $15.3 million.
"Battle: Los Angeles" came in third with $14.6 million.
"The Lincoln Lawyer" and "Paul" ranked fourth and fifth, respectively, with more than $13 million each.
The top 10 movies of the weekend:
- "Limitless," $19 million.
- "Rango," $15.3 million.
- "Battle: Los Angeles," $14.6 million.
- "The Lincoln Lawyer," $13.4 million.
- "Paul," $13.2 million.
- "Red Riding Hood," $7.3 million.
- "The Adjustment Bureau," $5.9 million.
- "Mars Needs Moms!" $5.3 million.
- "Beastly," $3.3 million.
- "Hall Pass," $2.6 million.
The Associated Press contributed to this report.