The 53-year-old actor plays himself on the new scripted show, which stars Amy Landecker as his wife Claire. Ben Shenkman, Omid Djalili, Duane Martin and Andrew Daly play Reiser's newfound acquaintances - husbands of Claire's friends and the fathers of the classmates of her and Reiser's children.
"I've noticed in the last four years that I've gotten more friendly with my guy friends," Reiser said in a video posted on the show's website. "Some of them are really good, solid friends, some of them - I don't even really know how I got them. I never chose them, but all right, I guess, we'll go to a ball game, sure. That turned out to be more universal among guys than I thought."
"The Paul Reiser Show" will air on April 14 between 8:30 p.m. and 9 p.m. ET instead of "Perfect Couples," which has been pulled from NBC's schedule. The network has not announced a return date for the show, which stars Olivia Munn and debuted in January.
Reiser, a comedian, played Paul Buchman on the show "Mad About You" alongside Helen Hunt between 1992 and 1999. He was nominated for an Emmy six times for his role. Before that, he and Greg Evigan starred on "My Two Dads" between 1987 and 1990.
In the last few years, he has starred in "The Thing About My Folks," a 2005 film that he also wrote, as well as several television movies. He also appeared as himself in the 2009 Adam Sandler film "Funny People," which depicted the life of a comedian.
Check out an interview with Paul Reiser below.