O'Donnell's new talk show will be produced at Harpo Studios on Chicago's West Side. Harpo executives announced the move on Tuesday.
O'Donnell is expected to return to daytime TV with a daily one-hour show on Own: Oprah Winfrey Network this fall.
In a statement Tuesday, Winfrey said she's delighted to welcome O'Donnell to the studio.
The final original episode of Winfrey's show is scheduled to air May 25.