The incident happened around 10:30 p.m. Thursday at the corner of Victory Boulevard and Fulton Street.
Officials said the victim was crossing outside of the crosswalk when he was struck by a car traveling westbound on Victory Boulevard.
The victim, described as a man between the ages 35 and 45 years old, was found 15 feet west of the intersection.
Authorities said a driver of a dark-colored sedan struck the man and did not stop.
The victim was transported to Providence Holy Cross Medical Center with severe injuries and was listed in critical condition.
Anyone with information was urged to call the Los Angeles Police Department at (877) LAPD-24-7 . Callers can remain anonymous.