The actors' career has already allowed him to branch out into every different film genre, but Brand is most at home where there is laughter.
"The genre in which I'm most happy is this, a genuinely funny, romantic comedy," Brand said. "To play a role made famous by the beautiful Dudley Moore opposite Helen Mirren? For me it was like some sort of wish fulfillment program."
Mirren plays Hobson, the caretaking role made famous in 1981 by the late Sir John Geilgud.
Brand says he can relate to the character, but adds he was not a loveable drunk like his onscreen alter ego.
"The kind of drunk I was a bit more crazy reckless and destructive," Brand said. "I was a terrible drug addict. Crack, heroin, alcohol, addicted to all of them."
"Eight years clean now and happily married," he added. "A fine testament to the power of love. Once I fell in love, my life changed direction and that's what happens to Arthur in this film. He falls in love and discovers a sense of purpose."
Brand loves working with Mirren. Last year, the two actors also co-starred in the Shakespearean drama, "The Tempest."
"If it were up to me, I'd spend my whole life on a movie set with Helen Mirren, then I'd drive her home, tuck her into bed, jump in, head beneath the blanket, heart full of love," Brand said.
"Arthur" is rated PG-13 and is in theaters now.