The proposed High Desert Corridor freeway would link the Antelope Valley (14) Freeway to Interstate 15 at Victorville.
The corridor would replace long stretches of routes 18 and 138. The two-lane roads have high fatality rates.
The new freeway's median might also be used for a high-speed rail corridor for trains linking Southern California and Las Vegas.
The public hearings will be held Monday night in Lancaster and Tuesday in Palmdale.