The company says it's recalling two lots of 100-milligram tablets of Topamax, sold between Oct. 19 and Dec. 28, 2010. The lot numbers are OKG110 and OLG222.
The health care giant has issued more than 20 product recalls in the last 1 1/2 years, many triggered by complaints of nauseating odors from the products or packaging.
Other recalls have involved joint replacement parts, contact lenses and medicines in syringes.
The continuing manufacturing lapses have hurt J&J's revenue and profit, as well as its reputation.
The Associated Press contributed to this report.