The event, which sold out in six days, is expected to bring out more than 80,000 people each day of the event at Indio's Empire Polo Grounds.
Kings of Leon is the big act for Friday, the first day of the event.
Saturday's lineup features Montreal-based indie rock band Arcade fire.
The festival will close on Sunday with The Strokes and Kanye West.
Organizers are warning fans not to buy any tickets from a third party. They say no paper tickets will be accepted at the event.
Wristbands were already mailed to pass-holders.
The city of Indio issued an advisory to residents warning them of street closures and possible delays caused by concert traffic.
Several streets just north of the Indio will be closed for the duration of the concert, including Madison and Hjorth streets between Avenues 49 and 50. Portions of Avenue 49 and 50 will be closed as well, city officials said.
City News Service contributed to this report.