But once she returns to her hometown, the killing begins all over again.
"This is really the beginning to a new trilogy and so I think it was suitable to wait 10 years to be separate from the other ones, even though it is connected to characters from the previous one," said director Wes Craven.
"I wasn't sure it was such a great idea and that was really, only because 10 years ago we all decided that we should probably leave it where it was," Campbell said.
Courteney Cox and David Arquette, two stars from the original, are also back.
The movie introduces some new characters into the mix.
"It's kind of a new film in and of itself but it remembers where it came from," Hayden Panettiere said. "It remembers the cliches of horror movies and really makes them work."
"Scream 4" is rated R.