David Arquette joined other stars at the Hollywood Bites Back! benefit show in Los Angeles on Saturday, to support the nonprofit Malaria No More.
Celebs like Elizabeth Banks ("30 Rock"), Ed Helms ("The Hangover"), B.J. Novak ("The Office"), Conan O'Brien, Sarah Silverman, Ellie Kemper ("The Office") and Jason Ritter were also on hand for the event, which took place at L.A. Live's Club Nokia.
"Comedy is my favorite thing," Arquette said. "It's a method of raising awareness for malaria. You get people laughing, you get people talking."
The event is an extension of Malaria No More's Comedy Fights Malaria campaign, which was launched in October 2010. For the campaign, 25 celebrities including John Mayer, Orlando Bloom, Elizabeth Banks, Ed Helms, B.J. Novak, Josh Grboan, Lake Bell, Ted Danson and Jeremy Piven created comedy-driven viral videos and broadcast PSAs to raise awareness about malaria.
Celebrities like Ed Helms, Nick Kroll, Paul Sheer, Riki Lindhome and Nastasha Leggero also traveled to Senegal in 2010 for the nonprofit.
"Malaria is no laughing matter, but we're always looking for new and unexpected ways to shine a spotlight on the issue," said Peter Chernin, Chairman and Co-Founder of Malaria No More. "We're lucky to have some of the best in the comedy business come together for Hollywood Bites Back! in support of our efforts to ensure that no child dies of this preventable and treatable disease."
Though malaria was eradicated in the United States 60-years ago, the preventable and treatable disease continues to claim the lives of 781,000 people every year, most commonly children under the age of five in Africa. Malaria No More seeks to end deaths from the disease in Africa by 2015.
"Malaria is treatable and it's something we can end," Arquette said.
Arquette currently stars in "Scream 4" alongside his separated wife, Courteney Cox. The couple recently took their 10-year-old daughter Coco to Disney World in Florida, where Arquette claims he tried to seduce Cox.
For more information on the fight against the disease or to donate, visit malarianomore.org.
Watch a PSA from Malaria No More below.