The film stars Johnny Depp as Captain Jack Sparrow and Oscar winner Penelope Cruz as his former girlfriend.
Thousands of fans lined Main Street USA on Saturday to catch a glimpse of the stars as they walked the red carpet.
The film franchise is based on a Disneyland ride.
This latest installment also stars Ian McShane, Geoffrey Rush and Rolling Stone's Keith Richards.
"I'm very happy to be involved in it at all and I have great fun doing it because it's not what I do usually you know, so for me it's kind of wow, interesting. It makes a change, you know," Richards said.
"Pirates of the Caribbean: On Stranger Tides" opens May 20.
Disney is the parent company of ABC7.