All north and southbound lanes through the Sepulveda Pass will be closed from Saturday, July 16 until the morning of Monday, July 18.
Crews will be tearing out the Mulholland Drive overpass.
This is the biggest planned freeway closure in California since the San Francisco Bay Bridge was closed two years ago.
It is expected to affect approximately 500,000 drivers.
Beat Carmageddon with ABC7
The 405 shuts down the weekend of July 16-17, and ABC7 Eyewitness News is your home for the latest traffic news and information. Follow @abc7 and @BeatCarmageddon on Twitter, and use the hash tag #abc7traffic.
ABC7 has also partnered with Waze to help navigate the traffic. Download the Waze app, which provides free turn-by-turn GPS navigation based on the live conditions of the road. Join the community of drivers in Southern California today and beat Carmageddon.