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OTRC: Christina Applegate's pilot 'Up All Night' picked up by NBC - see video

Christina Applegate, Will Arnett and Maya Rudolph star in NBC's new comedy, 'Up All Night' which premieres in the fall. (NBC)

Christina Applegate's new project "Up All Night" was officially picked up by NBC, marking the actress' return to television, two years after her old show "Samantha Who?" was canceled.

The pilot also stars "Arrested Development"'s Will Arnett as Applegate's husband and "Bridesmaids" actress Maya Rudolph as her boss and best friend.

In the new single-camera show, Applegate, 39, portrays an acerbic working mother, while Arnett plays her overwhelmed, but supportive stay-at-home husband.

The project was spearheaded by "Saturday Night Live" creator Lorne Michaels and writer Emily Spivey. Applegate is also one of the producers, her spokesperson had told OnTheRedCarpet.com.

In real life, Christina recently gave birth to her first daughter, Sadie, with musician Martyn LeNoble in January, Arnett just became a dad for the second time with wife, Amy Poehler, and Rudolph is currently pregnant with her third child.

Applegate is known for playing the main character on "Samantha Who?," a comedy series that ran between 2007 and 2009, and for her role as ditzy Kelly Bundy on the sitcom "Married With Children," which starred "Modern Family" actor Ed O'Neill as her misanthropic father Al and "Sons of Anarchy" star Katey Sagal as her mother Peg.

Applegate has in recent years appeared in movies such as "Cats and Dogs: The Revenge of Kitty Galore," "Going the Distance" and the 2011 comedy "Hall Pass."

Arnett has had a recurring role on the sitcom "30 Rock" for the past three years and played "George "Gob" Bluth II" on the cult comedy series "Arrested Development" between 2003 and 2006. He also starred on the short-lived show "Running Wilde" last year.

Meanwhile, Arnett is also set to guest-star on the season seven finale of "The Office" on May 19, which will be main actor Steve Carell's last show. Carell had played the egotistical boss Michael Scott since the show premiered in 2005 and had announced his plans for departure last year. NBC has not announced who will replace Carell.

"Up All Night" will air on Wednesdays at 8 p.m. on NBC. Watch a promo for the show below.

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