Anne Sinclair left the luxury lower Manhattan high-rise near Wall Street on Sunday morning.
Sinclair has stood by her husband since his arrest last Sunday. Strauss-Kahn, 62, is accused of sexually assaulting a maid in his suite at Manhattan's Sofitel.
He was released from Rikers Island jail on Friday on $1 million bail plus $5 million bond.
A crowd of international reporters and onlookers stands around the clock outside the apartment building at 71 Broadway where Strauss-Kahn was brought after another building rejected him, fearing a media frenzy.
The Associated Press contributed to this report.