"The Hangover Part II" took the No. 1 spot in Friday's box office, pulling in an estimated $30 million.
The R-rated comedy also grossed $31.7 million in its opening night on Thursday, for a cumulative $61.6 million in its first two days and is on track to gross $135 million in its first five days, according to the Hollywood Reporter.
"Kung Fu Panda 2" earned an estimated $13.2 million on Friday and a cumulative $19 million from its two days in theaters. The 3D cartoon is expected to gross up to $70 million in its five-day debut.
This Memorial Day weekend is gearing up to be one of the biggest box office weekends on record, if not the biggest. Meanwhile, "The Hangover Part II" is looking like it will be the best-performing film of the year so far.
In the movie, which is set for release during Memorial Day weekend, the four stars (Bradley Cooper, Zach Galifianakis, Ed Helms and Justin Bartha) travel to Thailand for Stu's wedding. Helms plays the character who famously lost a tooth in the first film and ends up with the now infamous Maori-inspired face tattoo the eve of his wedding in the sequel.
In the first movie, which hit theaters in 2009, hijinks ensued when the four arrived in Las Vegas for a bachelor party ahead of the wedding of Doug, played by Bartha.
A lawsuit over Tyson's tattoo threatened to push back the film's release, but the film opened in theaters on May 26, as scheduled.
When asked at the recent Los Angeles premiere what he thought of having Helm sport his tattoo for the movie, Tyson told OnTheRedCarpet.com host Rachel Smith he was "honored." Tyson appears in both the original "Hangover" film and its sequel, playing himself.
Watch a trailer for "The Hangover Part II" below.